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300-220 Conducting Threat Hunting and Defending using Cisco Technologies for Cybersecurity Exam Topics and Questions

Let's Practice Free Cisco 300-220 Questions Aligned with Official Exam Topics

Follows Cisco's official outline Updated 13 Oct, 2026 6 Topics
Reviewed by Emily White, Cisco 300-220 Certified Professional
Topic Content

This is the heaviest topic and it sets the conceptual foundation for everything that follows. You need to understand how hunting matures, how threats are modelled, and where detection tools fall short. The Pyramid of Pain and frameworks like MITRE ATT&CK appear throughout the exam, so weak coverage here will cost you across multiple domains. – Maturity, models and frameworks The Threat Hunting Maturity Model describes how an organisation progresses from reactive detection to proactive hunting, and the exam ties...

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The sample below tests your ability to apply a framework to observed behaviour and identify the correct classification without additional context.

Sample Questions for Topic 1 : Threat Hunting Fundamentals
Q1

Refer to the exhibit.

A security engineer notices that a Windows Batch script includes calls to suspicious APIs. How will the script affect the system when it is executed?

Topic Content

Where the first topic introduced the frameworks, this one asks you to choose and use them. You need to know when structured hunting is appropriate and when unstructured methods are better, and you need to prioritise attacks using both the Cyber Kill Chain and MITRE models. Ten per cent is a moderate weighting, but the skills tested here underpin the heavier topics that follow. – Selecting and applying models Different scenarios call for different threat modelling approaches. MITRE ATT&CK maps...

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The question that follows asks you to select the appropriate modelling approach given a specific operational context and constraint.

Sample Questions for Topic 2 : Threat modeling techniques
Q2

A threat hunter wants to detect fileless malware activity using Cisco Secure Endpoint. Which behavior would MOST strongly indicate fileless execution?

Topic Content

Attribution is hard, and this topic tests your ability to extract TTPs from incomplete data. You will work with logs, interpret actor behaviour, and decide whether observed activity is an authorised test or a real attack. At twenty per cent, this topic carries the same weight as the fundamentals, and it demands careful reading of evidence rather than pattern matching to known threat groups. – Extracting TTPs from logs and intelligence Logs do not announce an attacker's identity. You infer...

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The sample item below requires you to interpret observed activity and determine which artifact category provides the most durable basis for attribution.

Topic Content

This is the most operationally detailed topic. You need to know how to augment detection with scripting, hunt in cloud environments, analyse endpoint artifacts, and recognise command-and-control traffic. Memory-resident attacks and code-level analysis appear here, as do IoT considerations. Twenty per cent means this topic will test breadth and depth in equal measure. – Scripting, cloud, and endpoint analysis Python and PowerShell let you automate repetitive analysis tasks and enrich detection logic that commercial tools cannot express. The exam expects...

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The question below presents a hunting scenario and asks you to identify the technique or artifact that would confirm the presence of a specific threat behaviour.

Topic Content

Process is what turns individual techniques into repeatable capability. This topic asks you to identify memory-resident attacks, reverse engineer compromises, find detection gaps, and build runbooks that others can follow. You also need to recommend tools, configurations, and remediation strategies. Twenty per cent makes this one of the four pillars of the exam, and it rewards candidates who think in systems rather than one-off wins. – Memory attacks, reverse engineering, and detection gaps Identifying memory-resident attacks requires a process, not...

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The sample below asks you to interpret memory analysis output and determine the next step in the investigation process given the constraints described.

Topic Content

The final topic is about what happens after the hunt. You need to diagnose analytical gaps, recommend mitigations, advance your organisation's maturity, and communicate findings to stakeholders who may not be technical. Ten per cent is a smaller weight, but the skills tested here determine whether your hunting work translates into organisational change. – Integration, gaps, and mitigation Multiproduct integration means data from one tool enriches analysis in another. A SIEM correlates endpoint telemetry with network logs, or a threat...

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The question below tests your ability to recommend a change that addresses an identified gap and advances the organisation's hunting capability.

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